Location: SLC transporters @ b7ec0e1728a7 / Electrogenic cotransporter / params_BG_fast.cellml

Author:
Weiwei Ai <wai484@aucklanduni.ac.nz>
Date:
2024-05-27 15:41:10+12:00
Desc:
Update readme file
Permanent Source URI:
https://models.physiomeproject.org/workspace/b65/rawfile/b7ec0e1728a7d93333c64719ad8e2ef696837d3f/Electrogenic cotransporter/params_BG_fast.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="params_BG" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="./units.cellml">
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="fmol_per_s" units_ref="fmol_per_s"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="J_per_K_mol" units_ref="J_per_K_mol"/>
        <units name="mM" units_ref="mM"/>
        <units name="pL" units_ref="pL"/>
        <units name="fA" units_ref="fA"/>
        <units name="fF" units_ref="fF"/>
    </import>
    <units name="volt_per_s">
        <unit exponent="-1" units="second"/>
        <unit units="volt"/>
    </units>
    <component name="params_BG">
        <variable initial_value="8.31" name="R" public_interface="out" units="J_per_K_mol"/>
        <variable initial_value="293" name="T" public_interface="out" units="kelvin"/>
        <variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
        <variable initial_value="1.413e-07" name="K_Nai" public_interface="out" units="per_fmol"/>
        <variable name="q_Nai" public_interface="out" units="fmol"/>
        <variable initial_value="1.413e-07" name="K_Nao" public_interface="out" units="per_fmol"/>
        <variable name="q_Nao" public_interface="out" units="fmol"/>
        <variable initial_value="5.715e-06" name="K_Glci" public_interface="out" units="per_fmol"/>
        <variable name="q_Glci" public_interface="out" units="fmol"/>
        <variable initial_value="5.715e-06" name="K_Glco" public_interface="out" units="per_fmol"/>
        <variable name="q_Glco" public_interface="out" units="fmol"/>
        <variable initial_value="3.660" name="K_1" public_interface="out" units="per_fmol"/>
        <variable initial_value="14.0120792870912" name="q_init_1" public_interface="out" units="fmol"/>
        <variable initial_value="3.301e+02" name="K_2" public_interface="out" units="per_fmol"/>
        <variable initial_value="73.5789953233851" name="q_init_2" public_interface="out" units="fmol"/>
        <variable initial_value="3.207e+02" name="K_3" public_interface="out" units="per_fmol"/>
        <variable initial_value="8.32475221020042e-07" name="q_init_3" public_interface="out" units="fmol"/>
        <variable initial_value="3.207e+02" name="K_4" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00332766153324895" name="q_init_4" public_interface="out" units="fmol"/>
        <variable initial_value="9.053e+02" name="K_5" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0242668351720812" name="q_init_5" public_interface="out" units="fmol"/>
        <variable initial_value="0.314" name="K_6" public_interface="out" units="per_fmol"/>
        <variable initial_value="12.0160029265031" name="q_init_6" public_interface="out" units="fmol"/>
        <variable name="V0_Vm" public_interface="out" units="volt"/>
        <variable initial_value="0.3" name="z_zf1" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.3" name="z_zr1" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.7" name="z_zf6" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.7" name="z_zr6" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.515e+04" name="kappa_r1" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="6.237e+02" name="kappa_r2" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="0.156" name="kappa_r3" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="2.495e+04" name="kappa_r4" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="1.105e+02" name="kappa_r5" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="9.562" name="kappa_r6" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="9.089e-04" name="kappa_r7" public_interface="out" units="fmol_per_s"/>
        <variable initial_value="20" name="Nai" units="mM"/>
        <variable initial_value="100" name="Nao" units="mM"/>
        <variable initial_value="10e-3" name="Glci" units="mM"/>
        <variable initial_value="1e-12" name="Glco" units="mM"/>
        <variable initial_value="8.5e5" name="V_i" units="pL"/>
        <variable initial_value="8.5e5" name="V_o" units="pL"/>
        <variable name="t" public_interface="out" units="second"/>
        <variable initial_value="-0.05" name="V_E" public_interface="out" units="volt"/>
        <variable initial_value="-0.15" name="test_volt" units="volt"/>
        <variable name="rate_VE" units="volt_per_s"/>
        <variable initial_value="10e-3" name="dt" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>V0_Vm</ci>
                <ci>V_E</ci>
            </apply>
            <apply>
                <eq/>
                <ci>q_Nai</ci>
                <apply>
                    <times/>
                    <ci>Nai</ci>
                    <ci>V_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Nao</ci>
                <apply>
                    <times/>
                    <ci>Nao</ci>
                    <ci>V_o</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Glci</ci>
                <apply>
                    <times/>
                    <ci>Glci</ci>
                    <ci>V_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Glco</ci>
                <apply>
                    <times/>
                    <ci>Glco</ci>
                    <ci>V_o</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>V_E</ci>
                </apply>
                <ci>rate_VE</ci>
            </apply>
            <apply>
                <eq/>
                <ci>rate_VE</ci>
                <piecewise>
                    <piece>
                        <cn cellml:units="volt_per_s">0</cn>
                        <apply>
                            <lt/>
                            <ci>t</ci>
                            <cn cellml:units="second" type="e-notation">1204.75<sep/>-3</cn>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <ci>test_volt</ci>
                                <cn cellml:units="volt">0.05</cn>
                            </apply>
                            <ci>dt</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>t</ci>
                                <cn cellml:units="second" type="e-notation">1204.75<sep/>-3</cn>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>t</ci>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="second" type="e-notation">1204.75<sep/>-3</cn>
                                    <ci>dt</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <cn cellml:units="volt_per_s">0</cn>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>t</ci>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="second" type="e-notation">1204.75<sep/>-3</cn>
                                    <ci>dt</ci>
                                </apply>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>t</ci>
                                <cn cellml:units="second" type="e-notation">2984.75<sep/>-3</cn>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>test_volt</ci>
                                    <cn cellml:units="volt">0.05</cn>
                                </apply>
                            </apply>
                            <ci>dt</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>t</ci>
                                <cn cellml:units="second" type="e-notation">2984.75<sep/>-3</cn>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>t</ci>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="second" type="e-notation">2984.75<sep/>-3</cn>
                                    <ci>dt</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="volt_per_s">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
</model>